CSF3R T618I/BaF3
CBP73253
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| I. Introduction | |
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Cell Line Name： |
CSF3R T618I/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II. Background | |
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CSF3R T618I lies within the extracellular domain proximal to the transmembrane domain of the Csf3r protein (PMID: 23656643). T618I confers a gain of function to the Csf3r protein as demonstrated by increased proliferation and increased downstream Jak-Stat signaling in transformed cells in culture (PMID: 23656643). |
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| III. Representative Data | |
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1.WB of CSF3R T618I/BaF3 |
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2. Anti-proliferation assay Figure 2. Anti-proliferation assay of three reference compounds on the CSF3R T618I/BaF3. |
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