hCD44v9/4T1
CBPG0278
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| I. Background | |||
| CD44v9 是CD44 基因顺利获得选择性剪接产生的关键变异亚型，人类CD44 基因定位于11 号染色体短臂，全长约50kb，由20 个高度保守的外显子组成，CD44v9 正是纳入第9 号变异外显子编码序列的转录产物，经糖基化修饰后分子量远高于广泛表达的标准型CD44s。 该基因编码的蛋白在正常组织中表达极低，却在胃癌、非小细胞肺癌等多种上皮来源肿瘤中特异性高表达，是公认的肿瘤干细胞核心标志物。临床数据显示，75%的胃癌组织中可检测到CD44v9 阳性表达，其表达水平与肿瘤浸润深度、淋巴结转移、不良预后显著正相关，是评估肿瘤恶性程度的重要生物标志物。 |
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| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | CD44v9 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+ 10μg/ml Blasticidin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
IV. Representative Data Figure 1. Recombinant hCD44v9/4T1 stably expressing hCD44v9. |
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