hITGA2/MC-38
CBPG0275
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| I. Background | |
| ITGA2 又称整合素亚基α2,别名CD49B、GPⅠa,是位于人类5 号染色体5q11 .2 区域 的蛋白编码基因,编码由1181 个氨基酸组成的I 型跨膜蛋白,广泛表达于皮肤、肾上腺、 上皮细胞、内皮细胞等多种组织与细胞中。它作为胶原蛋白的核心跨膜受体,常与β1亚基 形成异二聚体,顺利获得胞外MIDAS 结构域特异性识别I 型、IV 型胶原的特征序列,介导血 小板与细胞外基质的黏附,其功能缺失与9 型血小板出血性疾病直接相关,相关自身抗体 还可引发新生儿同种免疫性血小板减少症。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | ITGA2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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